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Infect Immun. 1971 October; 4(4): 323-330
Copyright © 1971 American Society for Microbiology. All Rights Reserved.

Hemopoietic Colony-Forming Cell Responses in Mice Infected with Ectromelia Virus

Department of Microbiology, The Queen's University of Belfast, Belfast, Northern Ireland

ABSTRACT

The responses of in vitro colony-forming cells (granulocyte-macrophage progenitor cells) were studied in the bone marrow, spleen, and blood of mice after intraperitoneal injection of 10³ plaque-forming units of ectromelia virus. This study showed that a colony-forming cell response occurred during infection and was accompanied by an increase in the serum level of colony-stimulating factor and, at a later stage, colony-inhibiting factor. Changes in the proportions of colony-forming cells were not due to relative changes in other cell populations. The relationships between colony-forming cell responses and levels of infection were complex, higher levels of infection being associated with good colony-forming cell responses in bone marrow and apparently poor colony-forming cell responses in blood and spleen.