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Effects of an Interferon Inducer, Poly I:C, on Acute Ocular Infection Produced by Intracameral Inoculation of Toxoplasma gondii

¹ Francis I. Proctor Foundation, University of California, San Francisco, California 94122

ABSTRACT

A potent interferon inducer, synthetic polyinosinic acid-polycytidylic acid complex (poly I:C), was used prophylactically and therapeutically in experimental ocular Toxoplasma infections in rabbits. Daily intravenous injections of poly I:C alone or when combined with daily subconjunctival injections of the inducer delayed the appearance of conjunctivitis, corneal opacity, and iritis in Toxoplasma-infected eyes provided that the treatment was started 1 day before the infection. When the treatment was begun at the same time or 1 day after the infection, no delay in the production of the ocular lesions was noted. In no case was the treatment curative or completely suppressive.