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Eperythrozoon coccoides I. Effect on the Interferon Response in Mice

Departments of Microbiology and Pediatrics, University of Utah College of Medicine, Salt Lake City, Utah 84112
Departments of Microbiology and Pediatrics, University of Rochester School of Medicine, Rochester, New York 14620

ABSTRACT

Eperythrozoon coccoides is a common blood parasite of rodents and the etiological agent of a chronic infection present in many mouse colonies. After primary infection, mice develop a parasitemia and anemia followed by a chronic, latent infection. During the acute phase of infection, mice manifest a striking suppression of interferon production in response to induction with Newcastle disease virus, Chikungunya virus, and poly I:C. These data suggest that the reticuloendothelial system involvement with this agent is associated with impairment of the interferon response. The enhanced susceptibility of E. coccoides-infected animals to certain viral infections may be related to this suppression of interferon production.

¹ Present address: University of Lagos, College of Medicine Lagos, Nigeria.

This article has been cited by other articles:

• Neimark, H., Peters, W., Robinson, B. L., Stewart, L. B. (2005). Phylogenetic analysis and description of Eperythrozoon coccoides, proposal to transfer to the genus Mycoplasma as Mycoplasma coccoides comb. nov. and Request for an Opinion. Int. J. Syst. Evol. Microbiol. 55: 1385-1391 [Abstract] [Full Text]