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Influence of Escherichia coli Lipopolysaccharide on Histamine-Forming Capacity and Antibody Formation in Lymphoid Tissues ¹

^a Department of Veterinary Science, The Pennsylvania State University, University Park, Pennsylvania 16802

ABSTRACT

Mice were injected intraperitoneally with 50 µg of Escherichia coli lipopolysaccharide (LPS). The spleen tissue exhibited increased histamine-forming capacity (HFC) 4 hr later. When this increased HFC was produced within 12 hr after intraperitoneal injection of sheep red blood cells (SRBC), there was an enhanced anti-SRBC antibody response in the spleen. In mice experiencing an increased spleen HFC at 36 hr after injection of SRBC, there was a significant decrease in the number of antibody-producing cells. The injection of histidine decarboxylase inhibitors simultaneously with the LPS greatly reduced the stimulation of HFC and also the adjuvant activity of the LPS.

¹ Authorized for publication on 19 April 1971, as paper 3960 in the Journal Series of the Pennsylvania Agricultural Experiment Station.