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Activation of Lysosomal Enzymes in Rabies-Infected Tissue Culture Cells Without Accompanying Cytopathic Effect

^a Laboratory Investigations Unit, Viral Diseases Branch, Epidemiology Program, Center for Disease Control, Lawrenceville, Georgia 30245

ABSTRACT

Lactic dehydrogenase and ß-glucuronidase were assayed in tissue culture fluids and cellular lysates, respectively, from BHK-21/13S and Iota cell cultures infected with rabies virus. Activation of lysosomal enzymes was shown from the day 4 of infection on, without any indication of cytopathic effect.

¹ On leave from the Panamerican Zoonosis Center, Casilla de Correos 23, Ramos Mejía, Buenos Aires, Argentina.

² On leave from the Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Argentina