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Infect Immun. 1971 November; 4(5): 589-592
Copyright © 1971 American Society for Microbiology. All Rights Reserved.

Passive Protection of Mice Against Intraperitoneally Injected Vibrio cholerae by G and M Antibody

Department of Microbiology, The University of Texas Southwestern Medical School, Dallas, Texas 75235

ABSTRACT

Fractions of rabbit anti-Vibrio cholerae serum containing G antibodies were compared with fractions containing M antibodies for their ability to protect mice against lethal infection resulting from the intraperitoneal injection of organisms suspended in mucin. About twice as much G as M (estimated by quantitative precipitation) was required to protect against approximately 1,000 50% lethal doses when the antibody was given intraperitoneally 4 hr before challenge. When protective serum fractions were given subcutaneously, however, the amount of M required to protect was increased about 40-fold, whereas G was about equally effective subcutaneously and intraperitoneally.