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Infect Immun. 1984 August; 45(2): 518-521

Preparation of procoligenoids from Escherichia coli heat-labile enterotoxins.

R A Finkelstein, C V Sciortino, L C Rieke, M F Burks and M Boesman-Finkelstein

ABSTRACT

Heat-labile enterotoxins from Escherichia coli strains of porcine and human origin polymerize on heating to form high-molecular-weight aggregates, "procoligenoids," analogous to procholeragenoid derived from the cholera enterotoxin. This aggregation is accompanied by loss of biological activity (toxicity). Further heating results in the release of B-subunit oligomers, coligenoids, analogous to choleragenoid. Further studies are needed to determine whether, like procholeragenoid, the procoligenoids are superior antigens in stimulating gut immunity after parenteral administration.

Infect Immun. 1984 August; 45(2): 518-521






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