This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services E-mail this article to a friend Similar articles in this journal Similar articles in ASM journals Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Leijh, P C Articles by van Furth, R Search for Related Content PubMed PubMed Citation Articles by Leijh, P C Articles by van Furth, R

 Previous Article  |  Next Article 

Infect Immun. 1984 November; 46(2): 448-452

Effect of thioglycolate on phagocytic and microbicidal activities of peritoneal macrophages.

P C Leijh, T L van Zwet, M N ter Kuile and R van Furth

ABSTRACT

Brewer thioglycolate-elicited mouse peritoneal macrophages were as active as resident peritoneal macrophages in the phagocytosis of opsonized Staphylococcus epidermidis but were unable to kill ingested microorganisms. This decreased functional activity was restricted to Brewer thioglycolate-elicited macrophages, since peritoneal macrophages elicited with NIH thioglycolate, alone or supplemented with agar and methylene blue, were as active as resident peritoneal macrophages. No effect of agar on the functional activities of macrophages was observed. A defective intracellular killing by peritoneal macrophages due to Brewer thioglycolate was seen only after an intraperitoneal injection with thioglycolate, not after in vitro incubation of resident macrophages with thioglycolate. The results of this study show that, depending on the kind of thioglycolate used, the functional characteristics of elicited macrophages may alter. However, none of the forms of thioglycolate investigated induced the recruitment of activated macrophages.

---

Infect Immun. 1984 November; 46(2): 448-452

This article has been cited by other articles:

• Mylonas, K. J., Nair, M. G., Prieto-Lafuente, L., Paape, D., Allen, J. E. (2009). Alternatively Activated Macrophages Elicited by Helminth Infection Can Be Reprogrammed to Enable Microbial Killing. J. Immunol. 182: 3084-3094 [Abstract] [Full Text]  
• Hicks, A. M., Riedlinger, G., Willingham, M. C., Alexander-Miller, M. A., Von Kap-Herr, C., Pettenati, M. J., Sanders, A. M., Weir, H. M., Du, W., Kim, J., Simpson, A. J. G., Old, L. J., Cui, Z. (2006). Transferable anticancer innate immunity in spontaneous regression/complete resistance mice. Proc. Natl. Acad. Sci. USA 103: 7753-7758 [Abstract] [Full Text]  
• Olle, E. W., Sreekumar, A., Warner, R. L., McClintock, S. D., Chinnaiyan, A. M., Bleavins, M. R., Anderson, T. D., Johnson, K. J. (2005). Development of an Internally Controlled Antibody Microarray. Mol. Cell. Proteomics 4: 1664-1672 [Abstract] [Full Text]  
• Modarai, B., Burnand, K.G., Sawyer, B., Smith, A. (2005). Endothelial Progenitor Cells Are Recruited Into Resolving Venous Thrombi. Circulation 111: 2645-2653 [Abstract] [Full Text]  
• Hanayama, R., Tanaka, M., Miyasaka, K., Aozasa, K., Koike, M., Uchiyama, Y., Nagata, S. (2004). Autoimmune Disease and Impaired Uptake of Apoptotic Cells in MFG-E8-Deficient Mice. Science 304: 1147-1150 [Abstract] [Full Text]  
• Cook, A. D., Braine, E. L., Hamilton, J. A. (2003). The Phenotype of Inflammatory Macrophages Is Stimulus Dependent: Implications for the Nature of the Inflammatory Response. J. Immunol. 171: 4816-4823 [Abstract] [Full Text]  
• White, P., Liebhaber, S. A., Cooke, N. E. (2002). 129X1/SvJ Mouse Strain Has a Novel Defect in Inflammatory Cell Recruitment. J. Immunol. 168: 869-874 [Abstract] [Full Text]  
• Hamrick, T. S., Havell, E. A., Horton, J. R., Orndorff, P. E. (2000). Host and Bacterial Factors Involved in the Innate Ability of Mouse Macrophages To Eliminate Internalized Unopsonized Escherichia coli. Infect. Immun. 68: 125-132 [Abstract] [Full Text]