This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Mehta, R T Articles by Juliano, R L Search for Related Content PubMed PubMed Citation Articles by Mehta, R T Articles by Juliano, R L

 Previous Article  |  Next Article 

Infect Immun. 1985 February; 47(2): 429-433

Effect of liposomal amphotericin B on murine macrophages and lymphocytes.

ABSTRACT

The effect of liposome-encapsulated amphotericin B on mouse macrophages and on T- and B-lymphocyte functions in vitro was compared with that of free amphotericin B. Liposomal amphotericin B was generally less toxic than the free form of the drug. Low concentrations of free amphotericin B completely inhibited the serum-dependent induction of transglutaminase, a marker for macrophage differentiation, and production of superoxide anion by macrophages, whereas encapsulation of the drug within liposomes protected the cells from these adverse effects. Liposomal amphotericin B did not affect the blastogenic response of T cells compared with the free drug, which was inhibitory at high concentrations. Antibody production in vivo was inhibited partially by both free and liposomal amphotericin B. These results thus suggest that encapsulation of amphotericin B in liposomes reduces the immunosuppressive effects exerted by free amphotericin B. This provides further justification for therapeutic use of liposomal amphotericin B in systemic fungal infections (G. Lopez-Berestein, R. Mehta, R. L. Hopfer, K. Mills, L. Kasi, K. Mehta, V. Fainstein, M. Luna, E. M. Hersh, and R. L. Juliano, J. Infect. Dis. 147:939-945, 1983).

This article has been cited by other articles:

• Van Epps, H. L., Feldmesser, M., Pamer, E. G. (2003). Voriconazole Inhibits Fungal Growth without Impairing Antigen Presentation or T-Cell Activation. Antimicrob. Agents Chemother. 47: 1818-1823 [Abstract] [Full Text]  
• Kretschmar, M., Geginat, G., Bertsch, T., Walter, S., Hof, H., Nichterlein, T. (2001). Influence of Liposomal Amphotericin B on CD8 T-Cell Function. Antimicrob. Agents Chemother. 45: 2383-2385 [Abstract] [Full Text]