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Infect Immun. 1972 January; 5(1): 127-131
Copyright © 1972 American Society for Microbiology. All Rights Reserved.

Mycoplasmacidal Activity of Peroxidase-H₂O₂-Halide Systems ¹

^a Department of Pathology and Medical Research, St. Margaret's Hospital, Department of Obstetrics and Gynecology, Tufts University School of Medicine, and Department of Bacteriology, Harvard University School of Medicine, Boston, Massachusetts 02125

ABSTRACT

A mycoplasmacidal system consisting of myeloperoxidase (MPO)-containing granules, H₂O₂, and a halide is described. In all parameters measured, it appears to be identical to the MPO-H₂O₂-halide bactericidal system previously reported. It has a pH optimum of approximately 5.5 and an optimal MPO:H₂O₂ ratio of 1:25. The halide requirement can be satisfied by either chloride or iodide. Through the use of taurine or horseradish peroxidase substitution, chloride-mediated killing can be distinguished from iodide-mediated killing. The relationship of this mycoplasmacidal system to other mycoplasmacidal systems and to host surveillance of mycoplasma is discussed.

¹ This is paper number XXXV in a series entitled The Role of the Phagocyte in Host-Parasite Interactions.