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Infect Immun. 1972 January; 5(1): 48-54
Copyright © 1972 American Society for Microbiology. All Rights Reserved.

Relationship of Serogroups of Neisseria meningitidis II. R Variants of Neisseria meningitidis

^a Bacteriology Division and Epidemiology Division, Naval Medical Research Unit No. 4, Great Lakes, Illinois 60088

ABSTRACT

Meningococci isolated in primary cultures from nasopharyngeal carriers occasionally consisted of mixtures of smooth (S) and rough (R) strains. The R strains were separated from the S strains and their morphological and serological characteristics were studied. Some of these R strains reverted spontaneously to S strains which subsequently produced group-specific polysaccharide. Several R strains, grown in the presence of deoxyribonucleic acid from either an R strain of known parentage or an S strain, formed recombinants with serological group specificity.

¹ Present address: Institute for Medical Research, Putnam Memorial Hospital, Bennington, Vt. 05201.