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Field Studies of an Attenuated Venezuelan Equine Encephalomyelitis Vaccine (Strain TC-83)

U.S. Army Medical Research Unit, Panama, and Middle America Research Unit, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Balboa Heights, Canal Zone

ABSTRACT

A series of field studies using strain TC-83 attenuated Venezuelan equine encephalomyelitis vaccine in horses was made to determine the rate of seroconversions, the postvaccination viremia, and the possibility of adverse reactions to the vaccine. The rate of seroconversions varied from 50% in one study to 91 and 100% in two others. The highest level of viremia measured was 7 x 10³ to 8 x 10³ plaqueforming units per ml. No adverse reactions to the vaccine were observed in any horses, including 42 pregnant mares and their resulting foals.