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Photodynamic Treatment of Herpes Keratitis

Departments of Ophthalmology and of Virology and Epidemiology, Baylor College of Medicine, Houston, Texas 77025

ABSTRACT

Photodynamic inactivation of virus was tested as a potential therapeutic tool for herpesvirus-induced keratitis, which is a leading cause of blindness and disability. Experimental keratitis produced in rabbits by infection with herpesvirus isolated from a human periorbital lesion was treated with proflavine and light. The herpetic keratitis could be rapidly resolved by the dye-light treatment, whereas improvement was not seen in untreated rabbits, nor in those treated with light alone or dye alone.