This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Collins, F. M. Search for Related Content PubMed PubMed Citation Articles by Collins, F. M.

Salmonellosis in Orally Infected Specific Pathogen-Free C57B1 Mice

¹ Trudeau Institute, Saranac Lake, New York 12983

ABSTRACT

Specific pathogen-free C57B1 mice are 100 to 1,000 times as sensitive as CD-1 mice to intravenous or oral challenge by Salmonella enteritidis or S. gallinarum. Resistance to infection by S. pullorum was unaffected. Growth of Listeria monocytogenes and Mycobacterium bovis (BCG) in intravenously infected C57B1 mice was similar to that seen in CD-1 mice. Quantitative counts of viable S. enteritidis in the walls of the stomach, small intestine, cecum, and large intestine and in the corresponding intestinal contents showed that most of the oral challenge inoculum was rapidly inactivated so that, by 24 hr, less than 1% was still viable. Overnight starvation and pretreatment with bicarbonate solution increased the relative survival of the challenge approximately 10-fold. Despite the rapid and extensive inactivation of the oral inoculum within the normal intestine, significant numbers of salmonellae reached the liver and spleen by 48 hr, and this systemic infection was subsequently responsible for the death of a high proportion of the challenged animals.

This article has been cited by other articles:

• Handley, S. A., Dube, P. H., Miller, V. L. (2006). From the Cover: Histamine signaling through the H2 receptor in the Peyer's patch is important for controlling Yersinia enterocolitica infection. Proc. Natl. Acad. Sci. USA 103: 9268-9273 [Abstract] [Full Text]  
• Sebastiani, G., Blais, V., Sancho, V., Vogel, S. N., Stevenson, M. M., Gros, P., Lapointe, J.-M., Rivest, S., Malo, D. (2002). Host Immune Response to Salmonella enterica Serovar Typhimurium Infection in Mice Derived from Wild Strains. Infect. Immun. 70: 1997-2009 [Abstract] [Full Text]  
• Schwan, W. R., Huang, X.-Z., Hu, L., Kopecko, D. J. (2000). Differential Bacterial Survival, Replication, and Apoptosis-Inducing Ability of Salmonella Serovars within Human and Murine Macrophages. Infect. Immun. 68: 1005-1013 [Abstract] [Full Text]  
• Richter-Dahlfors, A., Buchan, A. M.J., Finlay, B. B. (1997). Murine Salmonellosis Studied by Confocal Microscopy: Salmonella typhimurium Resides Intracellularly Inside Macrophages and Exerts a Cytotoxic Effect on Phagocytes In Vivo. J. Exp. Med. 186: 569-580 [Abstract] [Full Text]