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Effect of an Interferon Stimulator, Polyinosinic: Polycytidylic Acid, on Experimental Fungus Infections

¹ Laboratory of Viral Diseases and Laboratory of Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014

ABSTRACT

In the present study, the administration of an interferon stimulator, polyinosinic: polycytidylic acid (In:Cn), increased the severity of both experimental Candida albicans and Coccidioides immitis infections in mice, as evidenced by earlier time of death and higher final mortality. In addition, kidney tissue levels of C. albicans at 3 and 5 days after infection were found to be about 40- to 300-fold higher in In:Cn treated mice than in control mice. Experimental Cryptococcus neoformans infection, however, was not significantly affected by In:Cn treatment.