This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Brune, K. Articles by Spitznagel, J. K. Search for Related Content PubMed PubMed Citation Articles by Brune, K. Articles by Spitznagel, J. K.

Microbicidal Activity of Peroxidaseless Chicken Heterophile Leukocytes

^a Department of Bacteriology and Immunology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27514

ABSTRACT

Polymorphonuclear leukocytes (PMN) of the domestic chicken lack myeloperoxidase and, therefore, may be useful for studies of myeloperoxidase-independent antimicrobial mechanisms. Before such studies were undertaken, it was important to investigate the antimicrobial capacity of these cells against species of opportunistic pathogens that cause infection in humans with defective PMN function. In vitro, chicken PMN, like normal human PMN, readily phagocytized and killed Staphylococcus albus. They also killed Serratia marcescens, Escherichia coli, and Candida albicans. Cytochemical methods confirmed the absence of myeloperoxidase from chicken PMN.

¹ Present address: Department of Pharmacology, University of Basel, Spitalstrasse 21, Basel, Switzerland.

This article has been cited by other articles:

• Henderson, S. C., Bounous, D. I., Lee, M. D. (1999). Early Events in the Pathogenesis of Avian Salmonellosis. Infect. Immun. 67: 3580-3586 [Abstract] [Full Text]