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Influence of Gonadectomy on Candida albicans Urinary Tract Infection in CFW Mice

Departments of Microbiology and Medicine, University of Arizona, College of Medicine, Tucson, Arizona 85724

ABSTRACT

Candida albicans appeared in the urine of approximately 80% of CFW mice of both sexes within 2 weeks after intraperitoneal inoculation. During a follow-up period of 10 weeks, candiduria tended to clear, but persisted in 37% of males as compared to only 16% in females. Autopsy kidney cultures yielded candida in 53% of males as compared to 25% of females. Urine cultures in both sexes when positive contained 10^3.5 to 10^4.5 candida/ml regardless of the outcome of the infection. Preinoculation gonadectomy in both sexes increased resistance to the infection but did not alter the quantitative aspects of candiduria.