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Infect Immun. 1972 March; 5(3): 383-388
Copyright © 1972 American Society for Microbiology. All Rights Reserved.

In Vivo Release of Previously Cleared Interferon by Cycloheximide

Thomas J. Chester, Erik De Clercq, Marc R. Nuwer and Thomas C. Merigan

Division of Infectious Diseases, Department of Medicine, Stanford University School of Medicine, Stanford, California 94305
Rega Institute for Medical Research, University of Leuven, Leuven, Belgium

ABSTRACT

The release of previously cleared interferon by cycloheximide was studied in the mouse. When cycloheximide was administered after either endogenous interferon stimulation or administration of exogenous interferon, the clearance of interferon from the blood stream was interrupted and a sharp rise in interferon titer occurred approximately 6 hr after cycloheximide administration followed by a rapid decline to low levels. This effect was observed with either interferon stimulated endogenously (by polyriboinosinic·polyribocytidylic acid), or homologous (mouse) or heterologous (rabbit) interferon administered exogenously. Serum protein concentrations also exhibited this rise and fall phenomenon after cycloheximide administration although the magnitude of the change in protein concentrations was less pronounced than that observed with interferon. Hematocrits, although elevated in mice receiving cycloheximide, did not exhibit this rise and fall phenomenon. Hence, cycloheximide administration leads to the release into the circulation of previously cleared interferon as well as other proteins.

Infect Immun. 1972 March; 5(3): 383-388
Copyright © 1972 American Society for Microbiology. All Rights Reserved.





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Copyright © 1972 by the American Society for Microbiology. All rights reserved.