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Cross-Protective Antigens of Neisseria meningitidis Obtained from Slaterus Group Y ¹

Biochemistry Laboratory, National Research Council of Canada, Ottawa 2, Ontario, Canada
Canadian Communicable Disease Centre, Tunney's Pasture, Ottawa, Ontario, Canada

ABSTRACT

An extraction of the cells of Neisseria meningitidis serogroup Y with an aqueous solution of calcium choride (0.9 M) has been shown to solubilize a number of antigens. By immunodiffusion, this mixture of antigens has been shown to react with its group-specific antiserum and also to cross-react with a number of other group-specific antisera. The cross-reacting antigen appears to be an antigen common to a number of other serogroups of meningococci, and there is some evidence that it is protein in nature. It has been demonstrated further that the calcium chloride extract contains a strong cross-protective antigen, as shown by its ability to provide good, active immunity in mice to both the homologous and heterologous serogroups of meningococci.

¹ National Research Council of Canada no. 12546.