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Association of Escherichia coli with the Small Intestinal Epithelium II. Variations in Association Index and the Relationship Between Association Index and Enterosorption in Pigs

^a National Animal Disease Laboratory, Veterinary Sciences Research Division, Agricultural Research Service, Ames, Iowa 50010

ABSTRACT

The association between small intestinal epithelium and enteropathogenic Escherichia coli (EEC) was studied in ligated intestinal loops of pigs and rabbits. The association indexes (degree of association) for each of two porcine EEC strains varied widely among pigs and independently of each other. Significant litter-to-litter variations in association indexes among colostrum-deprived newborn pigs were interpreted to be the result of congenital resistance to association with specific EEC in some pigs. Since enterosorption occurred in loops with low association indexes, it was not necessary for EEC to establish a high association index for them to cause enterosorption in ligated intestinal loops. Two strains of EEC which are enteropathogenic for humans caused enterosorption in ligated loops in pigs 3 weeks old or less but not in 6-week-old pigs.

¹ Visiting scientist from the University of Zürich, Switzerland, supported by a grant from the Kredit zur Förderung des akademischen Nachwuchses des Kantons Zürich.