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Staphylococcidal Capability of Rabbit Peritoneal Macrophages in Relation to Infection and Elicitation: Delayed-Type Hypersensitivity Without Increased Resistance

¹ U.S. Veterans Administration Hospital, Philadelphia, Pennsylvania 19104

ABSTRACT

The staphylococcidal capability of populations of peritoneal macrophages in rabbits has been measured before and after repeated infections with Staphylococcus aureus. Such rabbits after infection showed delayed-type hypersensitivity to S. aureus antigens, but the staphylococcidal capability of the peritoneal macrophages was not increased. This result at the cellular level is in agreement with previous assessment in vivo of the consequences of staphylococcal infection. Pathways to cell-mediated resistance, with and without delayed-type hypersensitivity, are presented.