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Infect Immun. 1972 June; 5(6): 905-908
Copyright © 1972 American Society for Microbiology. All Rights Reserved.

Adenovirus Susceptibility to Human Interferon During One-Step Replication ¹

¹ Department of Microbiology, University of Vermont College of Medicine, Burlington, Vermont 05401
² University of Illinois College of Medicine, Chicago, Illinois 60612

ABSTRACT

Susceptibility of adenovirus types 2, 7, and 12 to human interferon was measured in three human diploid cell strains during a single-cycle infection. Although the relative susceptibility of adenovirus to interferon varied in these cell strains, the final yield of each type in each cell strain decreased as the interferon dose increased. On the other hand, wide difference in interferon susceptibility of adenoviruses and vesicular stomatitis virus (VSV) was noted, as interferon doses above 100 units profoundly inhibited VSV but not the adenoviruses.

¹ Some aspects of this investigation were presented at the 70th Annual Meeting of the American Society for Microbiology, Boston, Mass., 26 April 1970.

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