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Alteration in Antibody Response Induced by Carbon Inhalation: a Model System ¹

^a Department of Veterinary Science and Center for Air Environment Studies, The Pennsylvania State University, University Park, Pennsylvania 16802

ABSTRACT

The immune response in mice to antigens given by intraperitoneal, intravenous, and inhalation routes was compared in control and carbon-dust exposed mice. The most pronounced effect, a decrease in antibody-forming cells and serum agglutinin titers, was observed when the carbon-treated animals were immunized with antigens in the form of aerosol. Similar results were obtained when the antigens were administered by intravenous or intraperitoneal route. In contrast 4-days of pre-exposure to carbon dust increased the number of antibody-forming cells in the mediastinal lymph nodes. However, this effect was transient and was not significant when the carbon pre-exposure was continued for 15 days.

¹ Center for Air Environment Studies publication no. 233-71.