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Selective Effects of Thermal Injury on Mouse Peritoneal Macrophages

Department of Anatomy, Michigan State University, East Lansing, Michigan 48823
² Department of Pediatrics, The University of Texas Medical Branch and Shriner's Burns Institute, Galveston, Texas 77025

ABSTRACT

Normal mice or mice burned 6 days previously were injected intraperitoneally with either saline or 50 µg of concanavalin A. Four days after the injection the peritoneal macrophages were collected and examined in vitro. Macrophages from concanavalin A-injected mice appeared activated because several in vitro parameters of activity were increased. Examination of macrophages from burned animals revealed a selective depression of macrophage activity.