This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Maheshwari, R K Articles by Friedman, R M Search for Related Content PubMed PubMed Citation Articles by Maheshwari, R K Articles by Friedman, R M

 Previous Article  |  Next Article 

Infect Immun. 1986 September; 53(3): 628-630

Recombinant human gamma interferon inhibits simian malaria.

ABSTRACT

Prophylactic treatment with 0.1 mg of human gamma interferon per kg (body weight) per day completely suppressed experimental infection with Plasmodium cynomolgi B sporozoites in rhesus monkeys. Treatment with lower doses partially suppressed this infection. Prophylactic treatment with human gamma interferon, however, had no protective effect against trophozoite-induced infection, suggesting that the interferon effect was limited to the exoerythrocytic stage of parasitic development.

This article has been cited by other articles:

• Oliveira, G. A., Kumar, K. A., Calvo-Calle, J. M., Othoro, C., Altszuler, D., Nussenzweig, V., Nardin, E. H. (2008). Class II-Restricted Protective Immunity Induced by Malaria Sporozoites. Infect. Immun. 76: 1200-1206 [Abstract] [Full Text]  
• Calvo-Calle, J. M., Oliveira, G. A., Watta, C. O., Soverow, J., Parra-Lopez, C., Nardin, E. H. (2006). A Linear Peptide Containing Minimal T- and B-Cell Epitopes of Plasmodium falciparum Circumsporozoite Protein Elicits Protection against Transgenic Sporozoite Challenge. Infect. Immun. 74: 6929-6939 [Abstract] [Full Text]  
• Ozwara, H., Langermans, J. A. M., Kocken, C. H. M., van der Wel, A., van der Meide, P. H., Vervenne, R. A. W., Mwenda, J. M., Thomas, A. W. (2003). Transfected Plasmodium knowlesi Produces Bioactive Host Gamma Interferon: a New Perspective for Modulating Immune Responses to Malaria Parasites. Infect. Immun. 71: 4375-4381 [Abstract] [Full Text]  
• Singh, R. P., Kashiwamura, S.-i., Rao, P., Okamura, H., Mukherjee, A., Chauhan, V. S. (2002). The Role of IL-18 in Blood-Stage Immunity Against Murine Malaria Plasmodium yoelii265 and Plasmodium bergheiANKA. J. Immunol. 168: 4674-4681 [Abstract] [Full Text]  
• Flanagan, K. L., Lee, E. A. M., Gravenor, M. B., Reece, W. H. H., Urban, B. C., Doherty, T., Bojang, K. A., Pinder, M., Hill, A. V. S., Plebanski, M. (2001). Unique T Cell Effector Functions Elicited by Plasmodium falciparum Epitopes in Malaria-Exposed Africans Tested by Three T Cell Assays. J. Immunol. 167: 4729-4737 [Abstract] [Full Text]  
• Vigario, A. M., Belnoue, E., Cumano, A., Marussig, M., Miltgen, F., Landau, I., Mazier, D., Gresser, I., Renia, L. (2001). Inhibition of Plasmodium yoelii blood-stage malaria by interferon {alpha} through the inhibition of the production of its target cell, the reticulocyte. Blood 97: 3966-3971 [Abstract] [Full Text]  
• Sauzet, J.-P., Perlaza, B.-L., Brahimi, K., Daubersies, P., Druilhe, P. (2001). DNA Immunization by Plasmodium falciparum Liver-Stage Antigen 3 Induces Protection against Plasmodium yoelii Sporozoite Challenge. Infect. Immun. 69: 1202-1206 [Abstract] [Full Text]