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Infect Immun. 1987 June; 55(6): 1533-1535

Cytotoxicity of Shiga toxin for primary cultures of human colonic and ileal epithelial cells.

ABSTRACT

Shiga toxin purified from Shigella dysenteriae 1 was cytotoxic to cultured epithelial cells from human colon and ileum. The cytotoxicity, which affected only about 50% of treated cells, was neutralized by rabbit antiserum monospecific for Shiga toxin and mediated by protein synthesis inhibition.

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