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Infect Immun. 1988 August; 56(8): 2006-2010

Susceptibility of germfree or antibiotic-treated adult mice to Cryptosporidium parvum.

J A Harp, M W Wannemuehler, D B Woodmansee and H W Moon

National Animal Disease Center, U.S. Department of Agriculture, Ames, Iowa 50010.

ABSTRACT

Adult mice are more resistant than neonatal mice to intestinal colonization with the protozoan parasite Cryptosporidium parvum. Development of a mature intestinal flora may play a role in this resistance. We compared susceptibilities to colonization with C. parvum in adult conventional mice, adult germfree mice, and adult conventional mice treated with oral antibiotics to deplete the intestinal flora. Germfree mice of both CD1 and BALB/c strains were colonized at day 7 following inoculation with C. parvum oocysts isolated from the feces of an infected, diarrheic calf. Age-matched conventional mice of the same strains were comparatively resistant to colonization. Conventional mice treated with antibiotics remained resistant to colonization. These results suggest that the microflora in the intestine was not the sole determinant of resistance or susceptibility to colonization. The germfree adult mouse as an experimental model of cryptosporidiosis is discussed.

Infect Immun. 1988 August; 56(8): 2006-2010




This article has been cited by other articles:

  • Okhuysen, P. C., Chappell, C. L., Sterling, C. R., Jakubowski, W., DuPont, H. L. (1998). Susceptibility and Serologic Response of Healthy Adults to Reinfection with Cryptosporidium parvum. Infect. Immun. 66: 441-443 [Abstract] [Full Text]  


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