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Infect Immun. 1989 October; 57(10): 2971-2976

Identification of antigens recognized by T cells in human leishmaniasis: analysis of T-cell clones by immunoblotting.

Section of Immunology and Cell Biology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892.

ABSTRACT

Immunity in human leishmaniasis is mediated by sensitized T lymphocytes; however, the antigens involved in eliciting this immunity have not been defined. We describe the generation of human T-lymphocyte clones derived from two patients with healed leishmaniasis. By use of one- and two-dimensional cellular immunoblotting techniques, we directly identified the parasite antigens recognized by these clones. To our knowledge, these are the first leishmanial antigens identified to which CD4+, gamma interferon-producing T cells from immune individuals have been shown to respond, the strategy may be of general use for the identification of antigens involved in immunity in this disease.

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