This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Cui, Z D Articles by Ogra, P L Search for Related Content PubMed PubMed Citation Articles by Cui, Z D Articles by Ogra, P L

 Previous Article  |  Next Article 

Infect Immun. 1989 March; 57(3): 739-744

Immunoprophylaxis of Chlamydia trachomatis lymphogranuloma venereum pneumonitis in mice by oral immunization.

Department of Pediatrics, State University of New York, Buffalo.

ABSTRACT

Groups of BALB/c mice were orally immunized with chlamydiae and challenged intranasally to determine whether oral immunization offers protection against pulmonary disease and to characterize the nature and kinetics of the chlamydial antibody response in the lung and other mucosal sites. Protection by oral immunization from chlamydial lung disease was demonstrated by lack of replication of the organism and the lack of chlamydial antigen in lung tissue. The chlamydial immunoglobulin A (IgA) antibody response was present at all body sites, reaching peak levels in the lung as well as in the serum. Classical IgA booster effect kinetics was observed after intranasal challenge, especially in the lung. Specific IgG antibody was detected at all body sites but at lower levels. Furthermore, animals immunized orally had no pneumonic process, as determined by histopathology. These studies also suggest that passively acquired specific serum IgG antibody may not significantly influence the course of mucosal replication of the organism. These observations indicate that oral immunization activating the gut-associated lymphoid tissue system gave total protection against chlamydial lung disease, suggesting migration of immunologically competent cells from the intestine to the lung.

This article has been cited by other articles:

• Perry, L. L., Hughes, S. (1999). Chlamydial Colonization of Multiple Mucosae following Infection by Any Mucosal Route. Infect. Immun. 67: 3686-3689 [Abstract] [Full Text]  
• Perry, L. L., Feilzer, K., Portis, J. L., Caldwell, H. D. (1998). Distinct Homing Pathways Direct T Lymphocytes to the Genital and Intestinal Mucosae in Chlamydia-Infected Mice. J. Immunol. 160: 2905-2914 [Abstract] [Full Text]