This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Engstrand, L Articles by Gustavsson, S Search for Related Content PubMed PubMed Citation Articles by Engstrand, L Articles by Gustavsson, S

 Previous Article  |  Next Article 

Infect Immun. 1989 March; 57(3): 827-832

Association of Campylobacter pylori with induced expression of class II transplantation antigens on gastric epithelial cells.

Department of Clinical Bacteriology, University Hospital, Uppsala, Sweden.

ABSTRACT

Campylobacter pylori was identified with immunoperoxidase staining and a mouse monoclonal antibody directed against C. pylori in gastric biopsy specimens from 24 patients with gastritis. C. pylori was not found in gastric biopsy specimens from six subjects with histologically normal mucosa. The monoclonal antibody, which was reactive with a surface protein of approximately 20 kilodaltons, was found to be specific for C. pylori, and the immunoperoxidase staining proved to be more sensitive and rapid than culture in detecting the organism. In the tissue specimens where C. pylori was detected with the monoclonal antibody, there was a strong expression of class II transplantation antigens on the epithelial cells and an increased number of T lymphocytes. These findings indicate that C. pylori may initiate local immune responses.

This article has been cited by other articles:

• Oksanen, A, Sankila, A, von Boguslawski, K, Sipponen, P, Rautelin, H (2005). Inflammation and cytokeratin 7/20 staining of cardiac mucosa in young patients with and without Helicobacter pylori infection. J. Clin. Pathol. 58: 376-381 [Abstract] [Full Text]  
• Akhiani, A. A., Schon, K., Lycke, N. (2004). Vaccine-Induced Immunity against Helicobacter pylori Infection Is Impaired in IL-18-Deficient Mice. J. Immunol. 173: 3348-3356 [Abstract] [Full Text]  
• Yamasaki, R., Yokota, K., Okada, H., Hayashi, S., Mizuno, M., Yoshino, T., Hirai, Y., Saitou, D., Akagi, T., Oguma, K. (2004). Immune response in Helicobacter pylori-induced low-grade gastric-mucosa-associated lymphoid tissue (MALT) lymphoma. J Med Microbiol 53: 21-29 [Abstract] [Full Text]  
• Cover, T. L., Krishna, U. S., Israel, D. A., Peek, R. M. Jr. (2003). Induction of Gastric Epithelial Cell Apoptosis by Helicobacter pylori Vacuolating Cytotoxin. Cancer Res. 63: 951-957 [Abstract] [Full Text]  
• Lehmann, F. S., Terracciano, L., Carena, I., Baeriswyl, C., Drewe, J., Tornillo, L., De Libero, G., Beglinger, C. (2002). In situ correlation of cytokine secretion and apoptosis in Helicobacter pylori-associated gastritis. Am. J. Physiol. Gastrointest. Liver Physiol. 283: G481-G488 [Abstract] [Full Text]  
• Fan, X., Gunasena, H., Cheng, Z., Espejo, R., Crowe, S. E., Ernst, P. B., Reyes, V. E. (2000). Helicobacter pylori Urease Binds to Class II MHC on Gastric Epithelial Cells and Induces Their Apoptosis. J. Immunol. 165: 1918-1924 [Abstract] [Full Text]  
• Smythies, L. E., Waites, K. B., Lindsey, J. R., Harris, P. R., Ghiara, P., Smith, P. D. (2000). Helicobacter pylori-Induced Mucosal Inflammation Is Th1 Mediated and Exacerbated in IL-4, But Not IFN-{gamma}, Gene-Deficient Mice. J. Immunol. 165: 1022-1029 [Abstract] [Full Text]  
• Yunoki, N., Yokota, K., Mizuno, M., Kawahara, Y., Adachi, M., Okada, H., Hayashi, S., Hirai, Y., Oguma, K., Tsuji, T. (2000). Antibody to Heat Shock Protein Can Be Used for Early Serological Monitoring of Helicobacter pylori Eradication Treatment. CVI 7: 574-577 [Abstract] [Full Text]  
• ZEVERING, Y, JACOB, L, MEYER, T F (1999). Naturally acquired human immune responses against Helicobacter pylori and implications for vaccine development. Gut 45: 465-474 [Full Text]  
• Yoshida, M., Wakatsuki, Y., Kobayashi, Y., Itoh, T., Murakami, K., Mizoguchi, A., Usui, T., Chiba, T., Kita, T. (1999). Cloning and Characterization of a Novel Membrane-Associated Antigenic Protein of Helicobacter pylori. Infect. Immun. 67: 286-293 [Abstract] [Full Text]  
• Lindholm, C., Quiding-Jarbrink, M., Lonroth, H., Hamlet, A., Svennerholm, A.-M. (1998). Local Cytokine Response in Helicobacter pylori-Infected Subjects. Infect. Immun. 66: 5964-5971 [Abstract] [Full Text]  
• Fan, X., Crowe, S. E., Behar, S., Gunasena, H., Ye, G., Haeberle, H., Van Houten, N., Gourley, W. K., Ernst, P. B., Reyes, V. E. (1998). The Effect of Class II Major Histocompatibility Complex Expression on Adherence of Helicobacter pylori and Induction of Apoptosis in Gastric Epithelial Cells: A Mechanism for T Helper Cell Type 1-mediated Damage. JEM 187: 1659-1669 [Abstract] [Full Text]  
• Faller, G, Steininger, H, Kranzlein, J, Maul, H, Kerkau, T, Hensen, J, Hahn, E G, Kirchner, T (1997). Antigastric autoantibodies in Helicobacter pylori infection: implications of histological and clinical parameters of gastritis. Gut 41: 619-623 [Abstract] [Full Text]