This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Matsuura, M Articles by Galanos, C Search for Related Content PubMed PubMed Citation Articles by Matsuura, M Articles by Galanos, C

 Previous Article  |  Next Article 

Infect Immun. 1990 April; 58(4): 935-937

Induction of hypersensitivity to endotoxin and tumor necrosis factor by sublethal infection with Salmonella typhimurium.

Max-Planck-Institut für Immunbiologie, Freiburg, Federal Republic of Germany.

ABSTRACT

The effect of sublethal infection with Salmonella typhimurium on the sensitivity of mice to the lethal activity of lipopolysaccharide (LPS) was studied in C3H/TifF mice. These mice are more resistant to S. typhimurium infection and survive inocula that are lethal for most other strains of mice. Infection of C3H/TifF mice with 2 x 10(4) CFU of S. typhimurium was without lethal effect. However, administration of LPS at different times after infection revealed that the sensitivity of the animals to the lethal activity of LPS increased exponentially, reaching a maximum by 6 to 8 days after infection. Thereafter, it decreased, reaching preinfection values about 4 weeks after inoculation. At the height of sensitivity, the animals were susceptible to less than 1 microgram of LPS compared with 100 or 200 micrograms in noninfected mice. The sensitization to LPS by infection was paralleled by a sensitization to tumor necrosis factor. The time course of development of sensitization to tumor necrosis factor, as well as the time course of its decrease and disappearance, was almost identical to that of LPS.

This article has been cited by other articles:

• Munford, R. S. (2005). Invited review: Detoxifying endotoxin: time, place and person. Innate Immunity 11: 69-84 [Abstract]  
• Jirillo, E., Caccavo, D., Magrone, T., Piccigallo, E., Amati, L., Lembo, A., Kalis, C., Gumenscheimer, M. (2002). Review: The role of the liver in the response to LPS: experimental and clinical findings. Innate Immunity 8: 319-327 [Abstract]  
• Salomao, R., Brunialti, M. K.C., Kallas, E. G., Martins, P. S., Rigato, O., Freudenberg, M. (2002). Lipopolysaccharide--cell interaction and induced cellular activation in whole blood of septic patients. Innate Immunity 8: 371-379 [Abstract]  
• Gumenscheimer, M., Mitov, I., Galanos, C., Freudenberg, M. A. (2002). Beneficial or Deleterious Effects of a Preexisting Hypersensitivity to Bacterial Components on the Course and Outcome of Infection. Infect. Immun. 70: 5596-5603 [Abstract] [Full Text]  
• Merlin, T., Gumenscheimer, M., Galanos, C., Freudenberg, M. A. (2001). TNF-{alpha} hyper-responses to Gram-negative and Gram-positive bacteria in Propionibacterium acnes primed or Salmonella typhimurium infected mice. Innate Immunity 7: 157-163 [Abstract]  
• Merlin, T., Sing, A., Nielsen, P. J., Galanos, C., Freudenberg, M. A. (2001). Inherited IL-12 Unresponsiveness Contributes to the High LPS Resistance of the Lpsd C57BL/10ScCr Mouse. J. Immunol. 166: 566-573 [Abstract] [Full Text]  
• Hochholzer, P., Lipford, G. B., Wagner, H., Pfeffer, K., Heeg, K. (2000). Role of Interleukin-18 (IL-18) during Lethal Shock: Decreased Lipopolysaccharide Sensitivity but Normal Superantigen Reaction in IL-18-Deficient Mice. Infect. Immun. 68: 3502-3508 [Abstract] [Full Text]  
• Rehli, M., Poltorak, A., Schwarzfischer, L., Krause, S. W., Andreesen, R., Beutler, B. (2000). PU.1 and Interferon Consensus Sequence-binding Protein Regulate the Myeloid Expression of the Human Toll-like Receptor 4 Gene. J. Biol. Chem. 275: 9773-9781 [Abstract] [Full Text]  
• Hayley, S., Brebner, K., Lacosta, S., Merali, Z., Anisman, H. (1999). Sensitization to the Effects of Tumor Necrosis Factor-alpha : Neuroendocrine, Central Monoamine, and Behavioral Variations. J. Neurosci. 19: 5654-5665 [Abstract] [Full Text]  
• Mastroeni, P., Harrison, J. A., Robinson, J. H., Clare, S., Khan, S., Maskell, D. J., Dougan, G., Hormaeche, C. E. (1998). Interleukin-12 Is Required for Control of the Growth of Attenuated Aromatic-Compound-Dependent Salmonellae in BALB/c Mice: Role of Gamma Interferon and Macrophage Activation. Infect. Immun. 66: 4767-4776 [Abstract] [Full Text]  
• Jackson, J. J., Kropp, H. (1996). Differences in mode of action of ( -lactam antibiotics influence morphology, LPS release and in vivo antibiotic efficacy. Innate Immunity 3: 201-218 [Abstract]