This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Flesch, I E
Right arrow Articles by Kaufmann, S H
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Flesch, I E
Right arrow Articles by Kaufmann, S H

 Previous Article  |  Next Article 

Infect Immun. 1990 August; 58(8): 2675-2677

Activation of tuberculostatic macrophage functions by gamma interferon, interleukin-4, and tumor necrosis factor.

I E Flesch and S H Kaufmann

Department of Medical Microbiology and Immunology, University of Ulm, Federal Republic of Germany.

ABSTRACT

The capacity of the cytokines gamma interferon (IFN-gamma), interleukin-4 (IL-4), and tumor necrosis factor (TNF) to activate tuberculostatic functions in murine bone marrow-derived macrophages (BMM phi) was investigated. In confirmation of earlier findings, IFN-gamma rendered BMM phi capable of inhibiting subsequent infection with Mycobacterium bovis. In contrast, IL-4 and TNF failed to inhibit mycobacterial growth. However, in already infected BMM phi, tuberculostasis was induced by subsequent stimulation with IL-4. Although TNF alone was ineffective, it showed synergy with IFN-gamma in the stimulation of tuberculostasis. Our data suggest that not only IFN-gamma but also IL-4 and TNF participate in the control of mycobacterial growth.

Infect Immun. 1990 August; 58(8): 2675-2677




This article has been cited by other articles:

  • Kalsdorf, B., Scriba, T. J., Wood, K., Day, C. L., Dheda, K., Dawson, R., Hanekom, W. A., Lange, C., Wilkinson, R. J. (2009). HIV-1 Infection Impairs the Bronchoalveolar T-Cell Response to Mycobacteria. Am. J. Respir. Crit. Care Med. 180: 1262-1270 [Abstract] [Full Text]  
  • Cirillo, S. L. G., Subbian, S., Chen, B., Weisbrod, T. R., Jacobs, W. R. Jr., Cirillo, J. D. (2009). Protection of Mycobacterium tuberculosis from Reactive Oxygen Species Conferred by the mel2 Locus Impacts Persistence and Dissemination. Infect. Immun. 77: 2557-2567 [Abstract] [Full Text]  
  • Ray, J. C. J., Flynn, J. L., Kirschner, D. E. (2009). Synergy between Individual TNF-Dependent Functions Determines Granuloma Performance for Controlling Mycobacterium tuberculosis Infection. J. Immunol. 182: 3706-3717 [Abstract] [Full Text]  
  • Gutierrez, M. G., Mishra, B. B., Jordao, L., Elliott, E., Anes, E., Griffiths, G. (2008). NF-{kappa}B Activation Controls Phagolysosome Fusion-Mediated Killing of Mycobacteria by Macrophages. J. Immunol. 181: 2651-2663 [Abstract] [Full Text]  
  • Scriba, T. J., Kalsdorf, B., Abrahams, D.-A., Isaacs, F., Hofmeister, J., Black, G., Hassan, H. Y., Wilkinson, R. J., Walzl, G., Gelderbloem, S. J., Mahomed, H., Hussey, G. D., Hanekom, W. A. (2008). Distinct, Specific IL-17- and IL-22-Producing CD4+ T Cell Subsets Contribute to the Human Anti-Mycobacterial Immune Response. J. Immunol. 180: 1962-1970 [Abstract] [Full Text]  
  • Torrado, E., Adusumilli, S., Fraga, A. G., Small, P. L. C., Castro, A. G., Pedrosa, J. (2007). Mycolactone-Mediated Inhibition of Tumor Necrosis Factor Production by Macrophages Infected with Mycobacterium ulcerans Has Implications for the Control of Infection. Infect. Immun. 75: 3979-3988 [Abstract] [Full Text]  
  • Kurtz, S., McKinnon, K. P., Runge, M. S., Ting, J. P.-Y., Braunstein, M. (2006). The SecA2 Secretion Factor of Mycobacterium tuberculosis Promotes Growth in Macrophages and Inhibits the Host Immune Response. Infect. Immun. 74: 6855-6864 [Abstract] [Full Text]  
  • Tjarnlund, A., Rodriguez, A., Cardona, P.-J., Guirado, E., Ivanyi, J., Singh, M., Troye-Blomberg, M., Fernandez, C. (2006). Polymeric IgR knockout mice are more susceptible to mycobacterial infections in the respiratory tract than wild-type mice. Int Immunol 18: 807-816 [Abstract] [Full Text]  
  • Banaiee, N., Kincaid, E. Z., Buchwald, U., Jacobs, W. R. Jr., Ernst, J. D. (2006). Potent Inhibition of Macrophage Responses to IFN-{gamma} by Live Virulent Mycobacterium tuberculosis Is Independent of Mature Mycobacterial Lipoproteins but Dependent on TLR2.. J. Immunol. 176: 3019-3027 [Abstract] [Full Text]  
  • Jeevan, A., McFarland, C. T., Yoshimura, T., Skwor, T., Cho, H., Lasco, T., McMurray, D. N. (2006). Production and Characterization of Guinea Pig Recombinant Gamma Interferon and Its Effect on Macrophage Activation. Infect. Immun. 74: 213-224 [Abstract] [Full Text]  
  • Cheung, B. K. W., Lee, D. C. W., Li, J. C. B., Lau, Y.-L., Lau, A. S. Y. (2005). A Role for Double-Stranded RNA-Activated Protein Kinase PKR in Mycobacterium-Induced Cytokine Expression. J. Immunol. 175: 7218-7225 [Abstract] [Full Text]  
  • Stenger, S (2005). Immunological control of tuberculosis: role of tumour necrosis factor and more. Ann Rheum Dis 64: iv24-iv28 [Abstract] [Full Text]  
  • Saunders, B. M., Tran, S., Ruuls, S., Sedgwick, J. D., Briscoe, H., Britton, W. J. (2005). Transmembrane TNF Is Sufficient to Initiate Cell Migration and Granuloma Formation and Provide Acute, but Not Long-Term, Control of Mycobacterium tuberculosis Infection. J. Immunol. 174: 4852-4859 [Abstract] [Full Text]  
  • Cho, H., Lasco, T. M., Allen, S. S., Yoshimura, T., McMurray, D. N. (2005). Recombinant Guinea Pig Tumor Necrosis Factor Alpha Stimulates the Expression of Interleukin-12 and the Inhibition of Mycobacterium tuberculosis Growth in Macrophages. Infect. Immun. 73: 1367-1376 [Abstract] [Full Text]  
  • Arruda, C., Valente-Ferreira, R. C., Pina, A., Kashino, S. S., Fazioli, R. A., Vaz, C. A. C., Franco, M. F., Keller, A. C., Calich, V. L. G. (2004). Dual Role of Interleukin-4 (IL-4) in Pulmonary Paracoccidioidomycosis: Endogenous IL-4 Can Induce Protection or Exacerbation of Disease Depending on the Host Genetic Pattern. Infect. Immun. 72: 3932-3940 [Abstract] [Full Text]  
  • Drennan, M. B., Nicolle, D., Quesniaux, V. J. F., Jacobs, M., Allie, N., Mpagi, J., Fremond, C., Wagner, H., Kirschning, C., Ryffel, B. (2004). Toll-Like Receptor 2-Deficient Mice Succumb to Mycobacterium tuberculosis Infection. Am. J. Pathol. 164: 49-57 [Abstract] [Full Text]  
  • Lasco, T. M., Yamamoto, T., Yoshimura, T., Allen, S. S., Cassone, L., McMurray, D. N. (2003). Effect of Mycobacterium bovis BCG Vaccination on Mycobacterium-Specific Cellular Proliferation and Tumor Necrosis Factor Alpha Production from Distinct Guinea Pig Leukocyte Populations. Infect. Immun. 71: 7035-7042 [Abstract] [Full Text]  
  • Waters, W. R., Palmer, M. V., Whipple, D. L., Carlson, M. P., Nonnecke, B. J. (2003). Diagnostic Implications of Antigen-Induced Gamma Interferon, Nitric Oxide, and Tumor Necrosis Factor Alpha Production by Peripheral Blood Mononuclear Cells from Mycobacterium bovis-Infected Cattle. CVI 10: 960-966 [Abstract] [Full Text]  
  • Engele, M., Castiglione, K., Schwerdtner, N., Wagner, M., Bolcskei, P., Rollinghoff, M., Stenger, S. (2002). Induction of TNF in Human Alveolar Macrophages As a Potential Evasion Mechanism of Virulent Mycobacterium tuberculosis. J. Immunol. 168: 1328-1337 [Abstract] [Full Text]  
  • El-Etr, S. H., Yan, L., Cirillo, J. D. (2001). Fish Monocytes as a Model for Mycobacterial Host-Pathogen Interactions. Infect. Immun. 69: 7310-7317 [Abstract] [Full Text]  
  • Duan, L., Gan, H., Arm, J., Remold, H. G. (2001). Cytosolic Phospholipase A2 Participates with TNF-{{alpha}} in the Induction of Apoptosis of Human Macrophages Infected with Mycobacterium tuberculosis H37Ra. J. Immunol. 166: 7469-7476 [Abstract] [Full Text]  
  • Boechat, N., Bouchonnet, F., Bonay, M., Grodet, A., Pelicic, V., Gicquel, B., Hance, A. J. (2001). Culture at High Density Improves the Ability of Human Macrophages to Control Mycobacterial Growth. J. Immunol. 166: 6203-6211 [Abstract] [Full Text]  
  • Grüber, C., Kulig, M., Bergmann, R., Guggenmoos-Holzmann, I., Wahn, U., the MAS-90 Study Group, (2001). Delayed Hypersensitivity to Tuberculin, Total Immunoglobulin E, Specific Sensitization, and Atopic Manifestation in Longitudinally Followed Early Bacille Calmette-Guerin-Vaccinated and Nonvaccinated Children. Pediatrics 107: 36e-36 [Abstract] [Full Text]  
  • Wigginton, J. E., Kirschner, D. (2001). A Model to Predict Cell-Mediated Immune Regulatory Mechanisms During Human Infection with Mycobacterium tuberculosis. J. Immunol. 166: 1951-1967 [Abstract] [Full Text]  
  • Roach, D. R., Briscoe, H., Saunders, B., France, M. P., Riminton, S., Britton, W. J. (2001). Secreted Lymphotoxin-{alpha} Is Essential for the Control of an Intracellular Bacterial Infection. JEM 193: 239-246 [Abstract] [Full Text]  
  • Ottones, F., Dornand, J., Naroeni, A., Liautard, J.-P., Favero, J. (2000). V{gamma}9V{delta}2 T Cells Impair Intracellular Multiplication of Brucella suis in Autologous Monocytes Through Soluble Factor Release and Contact-Dependent Cytotoxic Effect. J. Immunol. 165: 7133-7139 [Abstract] [Full Text]  
  • Briscoe, H., Roach, D. R., Meadows, N., Rathjen, D., Britton, W. J. (2000). A novel tumor necrosis factor (TNF) mimetic peptide prevents recrudescence of Mycobacterium bovis bacillus Calmette-Guerin (BCG) infection in CD4+ T cell-depleted mice. J. Leukoc. Biol. 68: 538-544 [Abstract] [Full Text]  
  • Fortsch, D., Rollinghoff, M., Stenger, S. (2000). IL-10 Converts Human Dendritic Cells into Macrophage-Like Cells with Increased Antibacterial Activity Against Virulent Mycobacterium tuberculosis. J. Immunol. 165: 978-987 [Abstract] [Full Text]  
  • Maeurer, M. J., Trinder, P., Hommel, G., Walter, W., Freitag, K., Atkins, D., Storkel, S. (2000). Interleukin-7 or Interleukin-15 Enhances Survival of Mycobacterium tuberculosis-Infected Mice. Infect. Immun. 68: 2962-2970 [Abstract] [Full Text]  
  • Roach, D. R., Briscoe, H., Baumgart, K., Rathjen, D. A., Britton, W. J. (1999). Tumor Necrosis Factor (TNF) and a TNF-Mimetic Peptide Modulate the Granulomatous Response to Mycobacterium bovis BCG Infection In Vivo. Infect. Immun. 67: 5473-5476 [Abstract] [Full Text]  
  • Kirman, J., McCoy, K., Hook, S., Prout, M., Delahunt, B., Orme, I., Frank, A., Le Gros, G. (1999). CTLA-4 Blockade Enhances the Immune Response Induced by Mycobacterial Infection but Does Not Lead to Increased Protection. Infect. Immun. 67: 3786-3792 [Abstract] [Full Text]  
  • Gomes, M. S., Paul, S., Moreira, A. L., Appelberg, R., Rabinovitch, M., Kaplan, G. (1999). Survival of Mycobacterium avium and Mycobacterium tuberculosis in Acidified Vacuoles of Murine Macrophages. Infect. Immun. 67: 3199-3206 [Abstract] [Full Text]  
  • Rojas, M., Olivier, M., Gros, P., Barrera, L. F., Garcia, L. F. (1999). TNF-{alpha} and IL-10 Modulate the Induction of Apoptosis by Virulent Mycobacterium tuberculosis in Murine Macrophages. J. Immunol. 162: 6122-6131 [Abstract] [Full Text]  
  • BONAY, M., BOUCHONNET, F., PELICIC, V., LAGIER, B., GRANDSAIGNE, M., LECOSSIER, D., GRODET, A., VOKURKA, M., GICQUEL, B., HANCE, A. J. (1999). Effect of Stimulation of Human Macrophages on Intracellular Survival of Mycobacterium bovis Bacillus Calmette-Guerin . Evaluation with a Mycobacterial Reporter Strain. Am. J. Respir. Crit. Care Med. 159: 1629-1637 [Abstract] [Full Text]  
  • JOHNSON, J. L., NYOLE, S., OKWERA, A., WHALEN, C. C., NSUBUGA, P., PEKOVIC, V., HUEBNER, R., WALLIS, R. S., MUGYENYI, P. N., MUGERWA, R. D., ELLNER, J. J., The Uganda-Case Western Reserve University Researc, (1998). Instability of Tuberculin and Candida Skin Test Reactivity in HIV-infected Ugandans. Am. J. Respir. Crit. Care Med. 158: 1790-1796 [Abstract] [Full Text]  
  • Coler, R. N., Skeiky, Y. A. W., Vedvick, T., Bement, T., Ovendale, P., Campos-Neto, A., Alderson, M. R., Reed, S. G. (1998). Molecular Cloning and Immunologic Reactivity of a Novel Low Molecular Mass Antigen of Mycobacterium tuberculosis. J. Immunol. 161: 2356-2364 [Abstract] [Full Text]  
  • Méndez-Samperio, P., Hernandez-Garay, M., Vazquez, A. N. (1998). Inhibition of Mycobacterium bovis BCG-Induced Tumor Necrosis Factor Alpha Secretion in Human Cells by Transforming Growth Factor beta. CVI 5: 588-591 [Abstract] [Full Text]  
  • Allendoerfer, R., Deepe, G. S. Jr. (1998). Blockade of Endogenous TNF-{alpha} Exacerbates Primary and Secondary Pulmonary Histoplasmosis by Differential Mechanisms. J. Immunol. 160: 6072-6082 [Abstract] [Full Text]  
  • Britton, W. J., Meadows, N., Rathjen, D. A., Roach, D. R., Briscoe, H. (1998). A Tumor Necrosis Factor Mimetic Peptide Activates a Murine Macrophage Cell Line To Inhibit Mycobacterial Growth in a Nitric Oxide-Dependent Fashion. Infect. Immun. 66: 2122-2127 [Abstract] [Full Text]  
  • Silver, R. F., Li, Q., Boom, W. H., Ellner, J. J. (1998). Lymphocyte-Dependent Inhibition of Growth of Virulent Mycobacterium tuberculosis H37Rv Within Human Monocytes: Requirement for CD4+ T Cells in Purified Protein Derivative-Positive, But Not in Purified Protein Derivative-Negative Subjects. J. Immunol. 160: 2408-2417 [Abstract] [Full Text]  
  • Via, L., Fratti, R., McFalone, M, Pagan-Ramos, E, Deretic, D, Deretic, V (1998). Effects of cytokines on mycobacterial phagosome maturation. J. Cell Sci. 111: 897-905 [Abstract]  
  • Newport, M. J., Huxley, C. M., Huston, S., Hawrylowicz, C. M., Oostra, B. A., Williamson, R., Levin, M. (1996). A Mutation in the Interferon-{gamma} -Receptor Gene and Susceptibility to Mycobacterial Infection. NEJM 335: 1941-1949 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»