This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Fayer, R Articles by Blagburn, B L Search for Related Content PubMed PubMed Citation Articles by Fayer, R Articles by Blagburn, B L

 Previous Article  |  Next Article 

Infect Immun. 1990 September; 58(9): 2962-2965

Immunotherapeutic efficacy of bovine colostral immunoglobulins from a hyperimmunized cow against cryptosporidiosis in neonatal mice.

Livestock and Poultry Sciences Institute, U.S. Department of Agriculture, Beltsville, Maryland 20705.

ABSTRACT

Infection with Cryptosporidium parvum, a ubiquitous protozoan parasite of virtually all mammals, can cause mild to severe diarrhea in immunocompetent hosts and life-threatening diarrhea in immunocompromised hosts. Passive immunotherapy of experimentally infected animals and naturally infected humans with hyperimmune bovine colostrum has been reported to be efficacious, whereas chemotherapy has not. In this study, the efficacy of specific immunoglobulin isotypes purified from bovine colostrum from a cow hyperimmunized with Cryptosporidium parvum was assessed in neonatal BALB/c mice. Mice were orally infected with oocysts and treated with whole whey immunoglobulin G1 (IgG1), IgG2, IgA, or IgM at six intervals from 22 to 66 h postinfection. In histologic sections of intestine examined at 72 h postinfection, the reduction in number of intestinal stages in treated mice versus untreated controls was very highly significant (P less than 0.0001). The greatest reduction in parasite number was found in mice treated with IgG1, IgA, or whey.

This article has been cited by other articles:

• Bhat, N., Joe, A., PereiraPerrin, M., Ward, H. D. (2007). Cryptosporidium p30, a Galactose/N-Acetylgalactosamine-specific Lectin, Mediates Infection in Vitro. J. Biol. Chem. 282: 34877-34887 [Abstract] [Full Text]  
• Godiwala, N. T., Vandewalle, A., Ward, H. D., Leav, B. A. (2006). Quantification of In Vitro and In Vivo Cryptosporidium parvum Infection by Using Real-Time PCR.. Appl. Environ. Microbiol. 72: 4484-4488 [Abstract] [Full Text]  
• Singh, I., Theodos, C., Tzipori, S. (2005). Recombinant Proteins of Cryptosporidium parvum Induce Proliferation of Mesenteric Lymph Node Cells in Infected Mice. Infect. Immun. 73: 5245-5248 [Abstract] [Full Text]  
• Riggs, M. W., Schaefer, D. A., Kapil, S. J., Barley-Maloney, L., Perryman, L. E. (2002). Efficacy of Monoclonal Antibodies against Defined Antigens for Passive Immunotherapy of Chronic Gastrointestinal Cryptosporidiosis. Antimicrob. Agents Chemother. 46: 275-282 [Abstract] [Full Text]  
• Schaefer, D. A., Auerbach-Dixon, B. A., Riggs, M. W. (2000). Characterization and Formulation of Multiple Epitope-Specific Neutralizing Monoclonal Antibodies for Passive Immunization against Cryptosporidiosis. Infect. Immun. 68: 2608-2616 [Abstract] [Full Text]  
• Griffiths, J. K., Theodos, C., Paris, M., Tzipori, S. (1998). The Gamma Interferon Gene Knockout Mouse: a Highly Sensitive Model for Evaluation of Therapeutic Agents against Cryptosporidium parvum. J. Clin. Microbiol. 36: 2503-2508 [Abstract] [Full Text]