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Infect Immun. 1991 December; 59(12): 4681-4683

Role of the galactose lectin of Entamoeba histolytica in adherence-dependent killing of mammalian cells.

L D Saffer and W A Petri Jr

Department of Medicine, University of Virginia Medical Center, Charlottesville 22908.

ABSTRACT

Entamoeba histolytica extracellular killing of host cells is contact dependent. Adherence to human colonic epithelial cells and mucins is mediated by a galactose-specific lectin. The effect on cytotoxicity of a panel of monoclonal antibodies (MAb) directed against the galactose lectin was tested. As expected, those MAb which inhibited adherence also decreased cytotoxicity. However, one antilectin MAb blocked cytotoxicity after adherence had occurred, indicating that the lectin has a role in cell killing that is distinct from its adherence function.

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Infect Immun. 1991 December; 59(12): 4681-4683

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