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Infect Immun. 1991 February; 59(2): 705-707

Modulation of Mycobacterium lepraemurium growth in murine macrophages: beneficial effect of tumor necrosis factor alpha and granulocyte-macrophage colony-stimulating factor.

M Denis

Bioscience I, ICI Pharmaceuticals, Mereside, Alderley Park, Macclesfield, Cheshire, United Kingdom.

ABSTRACT

Mycobacterium lepraemurium grew progressively in monolayers of Proteose Peptone-elicited macrophages from C57BL/6 mice. Treatment of macrophage monolayers with gamma interferon led to an enhancement of growth of M. lepraemurium in macrophages. Treatment with tumor necrosis factor alpha or granulocyte-macrophage colony-stimulating factor led to restriction of mycobacterial growth in macrophages.

Infect Immun. 1991 February; 59(2): 705-707






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Copyright © 1991 by the American Society for Microbiology. All rights reserved.