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Infect Immun. 1991 February; 59(2): 716-717

Lipopolysaccharide from Klebsiella pneumoniae inhibits Na+ absorption in canine tracheal epithelium.

First Department of Medicine, Tokyo Women's Medical College, Japan.

ABSTRACT

The effect of lipopolysaccharide (LPS) from Klebsiella pneumoniae on the bioelectric properties of canine cultured tracheal epithelium was examined. LPS decreased short-circuit current (Isc), and its effects on Isc were reduced when Isc was inhibited by amiloride and indomethacin. We speculate that LPS may selectively inhibit Na+ absorption through the inhibition of prostaglandin synthesis by airway epithelium.

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