This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Moore, V. L. Articles by Kato, M. Search for Related Content PubMed PubMed Citation Articles by Moore, V. L. Articles by Kato, M.

 Previous Article  |  Next Article 

Infect Immun. 1972 July; 6(1): 5-8
Copyright © 1972 American Society for Microbiology. All Rights Reserved.

Role of Cord Factor (Trehalose-6, 6'-Dimycolate) in Allergic Granuloma Formation in Rabbits

Department of Microbiology, Bowman Gray School of Medicine, Winston-Salem, North Carolina 27103
The Research Institute of Tuberculosis, Toneyama Hospital, National Sanatorium, Toyonaka, Osaka, Japan 560

ABSTRACT

The role of cord factor in BCG-induced pulmonary granulomas and local pulmonary delayed hypersensitivity (DH) was evaluated. Cord factor did not induce pulmonary granulomas comparable to those induced by killed BCG. The compound did not induce pulmonary DH that could be elicited by itself, purified protein derivative, or BCG. Cord factor-injected animals did not develop an accelerated pulmonary granulomatous response after challenge with killed BCG. Finally, cord factor did not elicit local pulmonary DH in BCG-sensitized animals. These results are discussed in relation to cord factor's role in antimicrobial immunity, granuloma formation, and antitumor immunity.