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Infect Immun. 1972 September; 6(3): 226-231
Copyright © 1972 American Society for Microbiology. All Rights Reserved.

Serological Diagnosis of Tropical Canine Pancytopenia by Indirect Immunofluorescence

Miodrag Ristic, David L. Huxsoll, Rita M. Weisiger, Paul K. Hildebrandt and M. B. A. Nyindo

Department of Veterinary Pathology and Hygiene, College of Veterinary Medicine, University of Illinois at Champaign-Urbana, Urbana, Illinois 61801
Division of Veterinary Medicine, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington, D.C. 20012

ABSTRACT

An indirect fluorescent-antibody test for detection and titration of antibodies to Ehrlichia canis, the causative agent of tropical canine pancytopenia, has been described. The organism propagated by an in vitro technique in canine blood monocytes served as an antigen in the test. The specificity of the test was revealed by absence of cross-reactivity between the antigen and sera from dogs infected with various common pathogens and specific sera against eight rickettsial species. The accuracy of the test was ascertained by isolation of the organism from reactor dogs located in and outside the United States. Histopathological examination of nine reactor dogs revealed plasmacytosis of meninges and kidneys in eight of them.

Infect Immun. 1972 September; 6(3): 226-231
Copyright © 1972 American Society for Microbiology. All Rights Reserved.



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