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Infect Immun. 1972 September; 6(3): 272-276
Copyright © 1972 American Society for Microbiology. All Rights Reserved.

Effect of Corynebacterium acnes on Interferon Production in Mice

¹ Department of Microbiology, Temple University Dental School, Philadelphia, Pennsylvania 19140
² Departments of Microbiology and Pediatrics, University of Utah College of Medicine, Salt Lake City, Utah 84112

ABSTRACT

Exposure to Corynebacterium acnes, the most prominent member of our normal skin flora, produces stimulation of lymphoid tissue and certain reticuloendothelial system functions, as well as the immune response. Alteration of the host response is extended by these studies to include changes in the pattern of interferon production in response to a representative group of inducing agents. Serum interferon levels induced by the injection of endotoxin in mice are enhanced, whereas interferon production after injection of Newcastle disease virus, Chikungunya virus, and polyinosinic:polycytidylic acid is depressed in animals inoculated with viable or nonviable C. acnes organisms.