This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Bohl, E. H. Articles by Saif, L. J. Search for Related Content PubMed PubMed Citation Articles by Bohl, E. H. Articles by Saif, L. J.

 Previous Article  |  Next Article 

Infect Immun. 1972 September; 6(3): 289-301
Copyright © 1972 American Society for Microbiology. All Rights Reserved.

Antibody Responses in Serum, Colostrum, and Milk of Swine After Infection or Vaccination with Transmissible Gastroenteritis Virus

^a Department of Veterinary Science, Ohio Agricultural Research and Development Center, Wooster, Ohio 44691

ABSTRACT

The antibody response of pregnant swine to transmissible gastroenteritis (TGE) virus was studied, with special reference to the titers and the immunoglobulin (Ig) class of TGE neutralizing antibodies in colostrum and milk. Animals vaccinated twice intramuscularly or intramammarily with live attenuated TGE virus developed high levels of antibodies in serum and colostrum, but the levels in milk declined markedly within a few days post-farrowing. In contrast, animals naturally or experimentally infected with virulent virus generally developed lower levels of antibodies in serum and colostrum but maintained higher levels in milk, as compared to the vaccinated animals. Gel filtration studies indicated that antibodies in milk from vaccinated animals were primarily of the IgG class, whereas those from the naturally or experimentally infected animals were primarily of the IgA class. The ability of sows to transmit a high degree of passive immunity to their suckling progeny was more closely associated with TGE antibodies of the IgA than the IgG class. Present evidence suggests that high levels of TGE antibodies of the IgA class occur in milk as a result of an infection of the intestinal tract. Probable reasons for this are discussed.

¹ Present address: Department of Veterinary Pathology, College of Veterinary Medicine, Haryana Agricultural University, Hissar, India.

² Present address: Escuela Nacional de Medicina Veterinaria, Cd. Universitaria, Mexico 20, D. F.

This article has been cited by other articles:

• Jung, K., Alekseev, K. P., Zhang, X., Cheon, D.-S., Vlasova, A. N., Saif, L. J. (2007). Altered Pathogenesis of Porcine Respiratory Coronavirus in Pigs due to Immunosuppressive Effects of Dexamethasone: Implications for Corticosteroid Use in Treatment of Severe Acute Respiratory Syndrome Coronavirus. J. Virol. 81: 13681-13693 [Abstract] [Full Text]  
• Sánchez, C. M., Izeta, A., Sánchez-Morgado, J. M., Alonso, S., Sola, I., Balasch, M., Plana-Durán, J., Enjuanes, L. (1999). Targeted Recombination Demonstrates that the Spike Gene of Transmissible Gastroenteritis Coronavirus Is a Determinant of Its Enteric Tropism and Virulence. J. Virol. 73: 7607-7618 [Abstract] [Full Text]