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Growth of Newcastle Disease Virus and Rubella Virus in Rheumatoid and Nonrheumatoid Synovial Cell Cultures

¹ Divisions of Infectious Diseases and Arthritis, Department of Internal Medicine, University of Utah College of Medicine, Salt Lake City, Utah 84112

ABSTRACT

Rheumatoid and nonrheumatoid synovial cell cultures were challenged with Newcastle disease virus and rubella virus in an attempt to confirm reports that rheumatoid synovial cells are relatively resistant to infection with these viruses. Newcastle disease virus caused complete cell destruction by day 7 in both rheumatoid and nonrheumatoid cultures, and peak virus titers were similar. Rubella virus replicated in both rheumatoid and nonrheumatoid synovial cell cultures, and no consistent differences in virus titers were detected. Rubella-infected cell lines were observed for up to 28 days and no virus-specific cytopathic effect was seen.