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Infect Immun. 1972 October; 6(4): 427-430
Copyright © 1972 American Society for Microbiology. All Rights Reserved.

Inhibition of Certain Deoxyribonucleic Acid Viruses by Liver Extracts

Helen H. Lee1 and T. W. Tinsley2

1 Veterinary Virus Research Institute, Cornell University, Ithaca, New York 14850
Unit of Invertebrate Virology, University of Oxford, Oxford, England

ABSTRACT

A proteinaceous substance was detected in the liver of several animal species that inhibited the multiplication of certain deoxyribonucleic acid, but not ribonucleic acid, viruses. Preliminary experiments suggested that its site of action was not extracellular. It did not inhibit virus by interfering with adsorption to cells. It was suggested that this inhibiting substance acts directly upon cells by interfering with viral synthesis.

Infect Immun. 1972 October; 6(4): 427-430
Copyright © 1972 American Society for Microbiology. All Rights Reserved.





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J. Bacteriol. J. Virol. Eukaryot. Cell
Microbiol. Mol. Biol. Rev. Clin. Vaccine Immunol. All ASM Journals

Copyright © 1972 by the American Society for Microbiology. All rights reserved.