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Herpesvirus hominis Type 2 Infections in Rabbits: Effect of Prior Immunization with Attenuated Mycobacterium bovis (BCG) Cells

Department of Microbiology and Stella Duncan Memorial Institute, University of Montana, Missoula, Montana 59801
Department of Biology, Northern State College, Aberdeen, South Dakota 57401

ABSTRACT

Angora, New Zealand, and Dutch-belted rabbits were tested for their susceptibility to graded doses of Herpesvirus hominis type 2 administered by vaginal instillation, intracorneal injection, and scarification of the cornea. Central nervous system involvement and death occurred after infection by the various routes employed. Prior immunization of Dutch-belted and New Zealand rabbits with viable Mycobacterium bovis (BCG) cells injected intravenously provided protection against subsequent infections with type 2 virus.