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Stimulation of Antibacterial Vaccination in Mice by Polyadenylic Acid: Polyuridylic Acid Complex

Laboratoire d'Immunologie, Faculté de Médecine, 37, Tours, France
IFFA-Merieux, 69, Lyon, France

ABSTRACT

The effect of polyadenylic acid:polyuridylic acid complex (poly A:U) on immunization was investigated in mice vaccinated by killed Brucella melitensis cells suspended in incomplete adjuvant or in saline. Addition of 300 µg of poly A:U to vaccines rendered 3 x 10⁸B. melitensis cells in saline as immunogenic as 3 x 10¹¹ cells in oil adjuvant against a severe B. abortus challenge. In the mouse and Brucella system, poly A:U exerts an adjuvant effect on immunity but does not stimulate production of circulating antibodies that could be demonstrated at the time of autopsy.