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Hyporeactivity of Infection: Potential Limitation to Therapeutic Use of Interferon-Inducing Agents

¹ Department of Microbiology and Pediatrics, University of Utah College of Medicine, Salt Lake City, Utah 84112

ABSTRACT

Interferon inducers are generally most effective as antiviral agents when used prophylactically. One possible explanation for this is that animals develop a state of hyporeactivity during the course of a virus infection. Such a progressive loss of capacity to produce interferon was observed with a representative group of interferon-inducing agents (polyinosinic-cytidylic acid, Tilorone hydrochloride, New-castle disease virus, or a strain of encephalomyocarditis virus) during the course of a model picornavirus infection in mice.

This article has been cited by other articles:

• Stringfellow, D. (1978). Prostaglandin restoration of the interferon response of hyporeactive animals. Science 201: 376-378 [Abstract]