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Infect Immun. 1972 November; 6(5): 779-784
Copyright © 1972 American Society for Microbiology. All Rights Reserved.

Comparative Studies of Plaque Variants Derived From a Florida Strain of Venezuelan Equine Encephalomyelitis Virus

¹ U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland 21701

ABSTRACT

Small- and large-plaque variants of a Florida strain (Fe 3-7c) of Venezuelan equine encephalomyelitis virus were studied in vivo and in vitro. The small-plaque variant was less virulent in mice, hamsters, and guinea pigs than the large-plaque variant. The variants could be distinguished by calcium phosphate chromatography. The implications of plaque variants within a mixed virus population are discussed.