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Infect Immun. 1972 December; 6(6): 1003-1007
Copyright © 1972 American Society for Microbiology. All Rights Reserved.

Electron Microscopy of the Toxin and Hemagglutinin of Type A Clostridium botulinum

Daniel A. Boroff, Sverker Nyberg and Stefan Höglund

Albert Einstein Medical Center, Philadelphia, Pennsylvania 19123
Wallenberg Laboratory, University of Uppsala, Uppsala, Sweden

ABSTRACT

Electron micrographs of the toxin and the hemagglutinin of type A Clostridium botulinum showed the toxin to be either round or disclike particles of 4 to 4.5 nm. These particles could also be seen as arranged in long strands or tubules of 9 nm in width. The hemagglutinin appeared as a crystalloid monolayer of stacked particles of 9 nm forming regularly arranged structures of 20 nm. Seen in cross section, these structures appeared as tubules with a lumen of 9 nm. The regularity of the angle of 83° to the long axis of the structure in which the individual particles were arranged suggested that the hemagglutinins formed a helix with sufficient space within its coil to admit the strands of the toxins. A model of the possible arrangement of the toxin and the hemagglutinin in the native state is proposed.

Infect Immun. 1972 December; 6(6): 1003-1007
Copyright © 1972 American Society for Microbiology. All Rights Reserved.



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