This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Sibold, C Articles by Hakenbeck, R Search for Related Content PubMed PubMed Citation Articles by Sibold, C Articles by Hakenbeck, R

 Previous Article  |  Next Article 

Infect Immun. 1992 October; 60(10): 4119-4126

Genetic relationships of penicillin-susceptible and -resistant Streptococcus pneumoniae strains isolated on different continents.

Max-Planck Institut für Molekulare Genetik, Berlin, Germany.

ABSTRACT

Sixty-six strains of Streptococcus pneumoniae isolated in different parts of the world, 46 resistant and 22 susceptible to penicillin, were subdivided by multilocus enzyme electrophoresis into 28 distinct electrophoretic types (ETs). The ETs to which penicillin-susceptible strains were assigned differed from those containing resistant isolates of the same serotype. Five common clones could be recognized among the penicillin-resistant bacteria by combining the ETs, the antigenic properties of penicillin-binding proteins PBP 1a and 2b, and the tetracycline and chloramphenicol resistance profiles. Two clones were found in Finland and were associated with capsular serotypes 6B and 23F, respectively. Two clones were from Spain (type 6B and 9V, respectively). The fifth clone was isolated in South Africa and in Spain and contained both serotype 23F isolates and one type 19F strain. The other resistant strains were represented by rare isolates distributed among 12 other ETs, confirming that resistance to penicillin has evolved by multiple branches. Because capsular type was mixed in several ETs, the results also demonstrate that it may vary among very closely related pneumococci.

This article has been cited by other articles:

• Lux, T., Nuhn, M., Hakenbeck, R., Reichmann, P. (2007). Diversity of Bacteriocins and Activity Spectrum in Streptococcus pneumoniae. J. Bacteriol. 189: 7741-7751 [Abstract] [Full Text]  
• Whalan, R. H., Funnell, S. G. P., Bowler, L. D., Hudson, M. J., Robinson, A., Dowson, C. G. (2006). Distribution and Genetic Diversity of the ABC Transporter Lipoproteins PiuA and PiaA within Streptococcus pneumoniae and Related Streptococci. J. Bacteriol. 188: 1031-1038 [Abstract] [Full Text]  
• Trzcinski, K., Thompson, C. M., Lipsitch, M. (2004). Single-Step Capsular Transformation and Acquisition of Penicillin Resistance in Streptococcus pneumoniae. J. Bacteriol. 186: 3447-3452 [Abstract] [Full Text]  
• Bogaert, D., Hermans, P. W. M., Grivea, I. N., Katopodis, G. S., Mitchell, T. J., Sluijter, M., de Groot, R., Beratis, N. G., Syrogiannopoulos, G. A. (2003). Molecular Epidemiology of Penicillin-Susceptible Non-{beta}-Lactam-Resistant Streptococcus pneumoniae Isolates from Greek Children. J. Clin. Microbiol. 41: 5633-5639 [Abstract] [Full Text]  
• Gertz, R. E. Jr., McEllistrem, M. C., Boxrud, D. J., Li, Z., Sakota, V., Thompson, T. A., Facklam, R. R., Besser, J. M., Harrison, L. H., Whitney, C. G., Beall, B. (2003). Clonal Distribution of Invasive Pneumococcal Isolates from Children and Selected Adults in the United States Prior to 7-Valent Conjugate Vaccine Introduction. J. Clin. Microbiol. 41: 4194-4216 [Abstract] [Full Text]  
• Bennett, D., Lennon, B., Humphreys, H., Cafferkey, M. (2003). Penicillin Susceptibility and Epidemiological Typing of Invasive Pneumococcal Isolates in the Republic of Ireland. J. Clin. Microbiol. 41: 3641-3648 [Abstract] [Full Text]  
• Malouin, F., Blais, J., Chamberland, S., Hoang, M., Park, C., Chan, C., Mathias, K., Hakem, S., Dupree, K., Liu, E., Nguyen, T., Dudley, M. N. (2003). RWJ-54428 (MC-02,479), a New Cephalosporin with High Affinity for Penicillin-Binding Proteins, Including PBP 2a, and Stability to Staphylococcal Beta-Lactamases. Antimicrob. Agents Chemother. 47: 658-664 [Abstract] [Full Text]  
• Robinson, D. A., Briles, D. E., Crain, M. J., Hollingshead, S. K. (2002). Evolution and Virulence of Serogroup 6 Pneumococci on a Global Scale. J. Bacteriol. 184: 6367-6375 [Abstract] [Full Text]  
• Bogaert, D., Ha, N. T., Sluijter, M., Lemmens, N., de Groot, R., Hermans, P. W. M. (2002). Molecular Epidemiology of Pneumococcal Carriage among Children with Upper Respiratory Tract Infections in Hanoi, Vietnam. J. Clin. Microbiol. 40: 3903-3908 [Abstract] [Full Text]  
• McGee, L., Goldsmith, C. E., Klugman, K. P. (2002). Fluoroquinolone resistance among clinical isolates of Streptococcus pneumoniae belonging to international multiresistant clones. J Antimicrob Chemother 49: 173-176 [Abstract] [Full Text]  
• Bogaert, D., Engelen, M. N., Timmers-Reker, A. J. M., Elzenaar, K. P., Peerbooms, P. G. H., Coutinho, R. A., de Groot, R., Hermans, P. W. M. (2001). Pneumococcal Carriage in Children in The Netherlands: a Molecular Epidemiological Study. J. Clin. Microbiol. 39: 3316-3320 [Abstract] [Full Text]  
• McGee, L., McDougal, L., Zhou, J., Spratt, B. G., Tenover, F. C., George, R., Hakenbeck, R., Hryniewicz, W., Lefevre, J. C., Tomasz, A., Klugman, K. P. (2001). Nomenclature of Major Antimicrobial-Resistant Clones of Streptococcus pneumoniae Defined by the Pneumococcal Molecular Epidemiology Network. J. Clin. Microbiol. 39: 2565-2571 [Abstract] [Full Text]  
• Johnson, A. P., Warner, M., George, R. C., Livermore, D. M. (2001). Activity of moxifloxacin against clinical isolates of Streptococcus pneumoniae from England and Wales. J Antimicrob Chemother 47: 411-415 [Abstract] [Full Text]  
• Hakenbeck, R., Balmelle, N., Weber, B., Gardes, C., Keck, W., de Saizieu, A. (2001). Mosaic Genes and Mosaic Chromosomes: Intra- and Interspecies Genomic Variation of Streptococcus pneumoniae. Infect. Immun. 69: 2477-2486 [Abstract] [Full Text]  
• Bogaert, D., Syrogiannopoulos, G. A., Grivea, I. N., de Groot, R., Beratis, N. G., Hermans, P. W. M. (2000). Molecular Epidemiology of Penicillin-Nonsusceptible Streptococcus pneumoniae among Children in Greece. J. Clin. Microbiol. 38: 4361-4366 [Abstract] [Full Text]  
• Overweg, K., Bogaert, D., Sluijter, M., Yother, J., Dankert, J., de Groot, R., Hermans, P. W. M. (2000). Genetic Relatedness within Serotypes of Penicillin-Susceptible Streptococcus pneumoniae Isolates. J. Clin. Microbiol. 38: 4548-4553 [Abstract] [Full Text]  
• Beall, B., Gherardi, G., Facklam, R. R., Hollingshead, S. K. (2000). Pneumococcal pspA Sequence Types of Prevalent Multiresistant Pneumococcal Strains in the United States and of Internationally Disseminated Clones. J. Clin. Microbiol. 38: 3663-3669 [Abstract] [Full Text]  
• Zhou, J., Enright, M. C., Spratt, B. G. (2000). Identification of the Major Spanish Clones of Penicillin-Resistant Pneumococci via the Internet Using Multilocus Sequence Typing. J. Clin. Microbiol. 38: 977-986 [Abstract] [Full Text]  
• Gherardi, G., Inostrozo, J. S., O'ryan, M., Prado, V., Prieto, S., Arellano, C., Facklam, R. R., Beall, B. (1999). Genotypic Survey of Recent beta -Lactam-Resistant Pneumococcal Nasopharyngeal Isolates from Asymptomatic Children in Chile. J. Clin. Microbiol. 37: 3725-3730 [Abstract] [Full Text]  
• Fitoussi, F., Doit, C., Geslin, P., Bingen, E. (1999). Killing Activities of Trovafloxacin Alone and in Combination with beta -Lactam Agents, Rifampin, or Vancomycin against Streptococcus pneumoniae Isolates with Various Susceptibilities to Extended-Spectrum Cephalosporins at Concentrations Clinically Achievable in Cerebrospinal Fluid. Antimicrob. Agents Chemother. 43: 2372-2375 [Abstract] [Full Text]  
• Enright, M. C., Fenoll, A., Griffiths, D., Spratt, B. G. (1999). The Three Major Spanish Clones of Penicillin-Resistant Streptococcus pneumoniae Are the Most Common Clones Recovered in Recent Cases of Meningitis in Spain. J. Clin. Microbiol. 37: 3210-3216 [Abstract] [Full Text]  
• Ip, M., Lyon, D. J., Yung, R. W. H., Chan, C., Cheng, A. F. B. (1999). Evidence of Clonal Dissemination of Multidrug-Resistant Streptococcus pneumoniae in Hong Kong. J. Clin. Microbiol. 37: 2834-2839 [Abstract] [Full Text]  
• Llull, D., Munoz, R., Lopez, R., Garcia, E. (1999). A Single Gene (tts) Located outside the cap Locus Directs the Formation of Streptococcus pneumoniae Type 37 Capsular Polysaccharide: Type 37 Pneumococci Are Natural, Genetically Binary Strains. J. Exp. Med. 190: 241-252 [Abstract] [Full Text]  
• Shi, Z.-Y., Enright, M. C., Wilkinson, P., Griffiths, D., Spratt, B. G. (1998). Identification of Three Major Clones of Multiply Antibiotic-Resistant Streptococcus pneumoniae in Taiwanese Hospitals by Multilocus Sequence Typing. J. Clin. Microbiol. 36: 3514-3519 [Abstract] [Full Text]  
• Marchese, A., Ramirez, M., Schito, G. C., Tomasz, A. (1998). Molecular Epidemiology of Penicillin-Resistant Streptococcus pneumoniae Isolates Recovered in Italy from 1993 to 1996. J. Clin. Microbiol. 36: 2944-2949 [Abstract] [Full Text]  
• Rudolph, K. M., Parkinson, A. J., Roberts, M. C. (1998). Molecular Analysis by Pulsed-Field Gel Electrophoresis and Antibiogram of Streptococcus pneumoniae Serotype 6B Isolates from Selected Areas within the United States. J. Clin. Microbiol. 36: 2703-2707 [Abstract] [Full Text]