This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Dziegiel, M Articles by Riley, E M Search for Related Content PubMed PubMed Citation Articles by Dziegiel, M Articles by Riley, E M

Immunoglobulin M and G antibody responses to Plasmodium falciparum glutamate-rich protein: correlation with clinical immunity in Gambian children.

Department of Infection-Immunology, Statens Seruminstitut, Copenhagen, Denmark.

ABSTRACT

The aims of the present study were to describe the age-related immunoglobulin M (IgM) and IgG response to part of a 220-kDa glutamate-rich protein (GLURP) from Plasmodium falciparum and to determine possible correlations of possession of these antibodies with malaria morbidity. IgM and IgG levels were measured with a recombinant fusion protein consisting of the carboxy-terminal 783 amino acids of the GLURP. Samples for the study were obtained during a longitudinal malaria morbidity survey performed in The Gambia; cross-sectional surveys were performed at the beginning of the transmission season in May and in October. Seropositivity rates increased with age to a maximum of 77% for IgM and 95% for IgG in adults. High prevalences of seropositivity were associated with certain human leukocyte antigen class II alleles (DRw8, DR9, DR7, DR4, DQw7, and DQw2) or haplotypes. The relationship between anti-GLURP489-1271 antibodies and clinical immunity is not clear; asymptomatically infected children aged 5 to 8 years had significantly higher levels of IgG than clinically ill children of the same age, suggesting that antibodies to the carboxy-terminal part of the GLURP may contribute to immunity to P. falciparum. However, this was not significant for younger children.

This article has been cited by other articles:

• PRATT-RICCIO, L. R., LIMA-JUNIOR, J. C., CARVALHO, L. J. M., THEISEN, M., ESPINDOLA-MENDES, E. C., SANTOS, F., OLIVEIRA-FERREIRA, J., GOLDBERG, A. C., DANIEL-RIBEIRO, C. T., BANIC, D. M. (2005). ANTIBODY RESPONSE PROFILES INDUCED BY PLASMODIUM FALCIPARUM GLUTAMATE-RICH PROTEIN IN NATURALLY EXPOSED INDIVIDUALS FROM A BRAZILIAN AREA ENDEMIC FOR MALARIA. Am J Trop Med Hyg 73: 1096-1103 [Abstract] [Full Text]  
• Soe, S., Theisen, M., Roussilhon, C., Aye, K.-S., Druilhe, P. (2004). Association between Protection against Clinical Malaria and Antibodies to Merozoite Surface Antigens in an Area of Hyperendemicity in Myanmar: Complementarity between Responses to Merozoite Surface Protein 3 and the 220-Kilodalton Glutamate-Rich Protein. Infect. Immun. 72: 247-252 [Abstract] [Full Text]  
• Oeuvray, C., Theisen, M., Rogier, C., Trape, J.-F., Jepsen, S., Druilhe, P. (2000). Cytophilic Immunoglobulin Responses to Plasmodium falciparum Glutamate-Rich Protein Are Correlated with Protection against Clinical Malaria in Dielmo, Senegal. Infect. Immun. 68: 2617-2620 [Abstract] [Full Text]  
• Johnson, A., Leke, R., Harun, L., Ginsberg, C., Ngogang, J., Stowers, A., Saul, A., Quakyi, I. A. (2000). Interaction of HLA and Age on Levels of Antibody to Plasmodium falciparum Rhoptry-Associated Proteins 1 and 2. Infect. Immun. 68: 2231-2236 [Abstract] [Full Text]  
• Theisen, M., Soe, S., Oeuvray, C., Thomas, A. W., Vuust, J., Danielsen, S., Jepsen, S., Druilhe, P. (1998). The Glutamate-Rich Protein (GLURP) of Plasmodium falciparum Is a Target for Antibody-Dependent Monocyte-Mediated Inhibition of Parasite Growth In Vitro. Infect. Immun. 66: 11-17 [Abstract] [Full Text]