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Infect Immun. 1993 January; 61(1): 142-145

T-lymphocyte response in a guinea pig model of tuberculous pleuritis.

S W Phalen and D N McMurray

Department of Medical Microbiology and Immunology, College of Medicine, Texas A&M University Health Science Center, College Station 77843.

ABSTRACT

The ability to induce tuberculous pleuritis in Mycobacterium bovis BCG-vaccinated guinea pigs was investigated as a model of human disease. A pleural effusion of 5 to 10 ml was obtained 6 to 7 days after the bilateral pleural injection of a suspension of heat-killed M. tuberculosis cells. Histological lesions were indicative of granulomatous pleuritis. Comparative studies of T lymphocytes obtained from pleural fluid and peripheral blood revealed increased antigen-driven lymphoproliferation and E rosette formation in pleural effusion lymphocytes. The CD2+ T-lymphocyte population appeared to be expanded or concentrated in pleural fluid, suggesting a compartmentalization of antigen-reactive T lymphocytes. These data demonstrate that experimental tuberculous pleuritis with effusion, closely resembling the human disease, can be produced in BCG-vaccinated guinea pigs.

Infect Immun. 1993 January; 61(1): 142-145




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